María Jesús Yebra Yebra

mariajesus-yebrayebra.jpg

María Jesús Yebra Yebra

Food Biotechnology

ext: 435171

e-mail:

yebra@iata.csic.es

Researcher ID:

H-4665-2012

Orcid:

ID link

Ver mis publicaciones

Biography

RESEARCH INTEREST
Dr. Yebra has extensive experience working on carbohydrate metabolism, regulation and molecular genetics of lactic acid bacteria. In the last few years she is interested in elucidating the role of human milk oligosaccharides (HMOs) in infant gut bacterial colonization. Human milk contains a large number of oligosaccharides and much evidence suggests that they are associated with the protective effect of human milk against gastroenteritis through its prebiotic effect, thus stimulating beneficial bacteria growth in the colon, but also through competitive inhibition of binding (anti-adhesion) of entero-pathogens to the host cells. The general objectives of the lab are (i) the molecular and functional characterization of the HMOs metabolic pathways in lactic acid bacteria; (ii) evaluation of the HMOs prebiotic activity and (iii) the analysis of the blocking activity exerted by specific HMOs into the pathogens attachment to their receptors. Since oligosaccharides are abundant in human milk but not in infant formula, we are also interested in the identification, and molecular and functional analysis of glycosidases to synthesize HMOs-like through their transglycosylation activity. Another research area of the lab is the development of metabolic engineering strategies for the production of biotechnological important metabolites in lactic acid bacteria.

EDUCATION
B.S. Biology, University of Oviedo, Spain, 1986
Ph.D. Biology, University of Oviedo, Spain, 1991

SCIENTIFIC AND PROFESSIONAL ACTIVITIES
Postdoctoral position, Wayne State University, Detroit, USA, 1992-1994
Research Staff, IATA-CSIC, Valencia, Spain, since 1995

Team

Victor Garcia Telles

Irene Boscá Sánchez

Eva Maria Moya Gonzalvez

Projects

PID2023-148094OB-C21

Evaluación de la función de los N-glicanos y O-glicanos de las glicoproteinas de la leche en la interacción de bifidobacterium y bacterias enteropatógenas

PID2020-115403RB-C21

Identificación y caracterización de nuevas enzimas glicosidasas del metagenoma de la microbiota intestinal de niños lactantes para su aplicación en alimentos funcionales

AGL2017-84165-C2-1-R

Modulación de la microbiota gastrointestinal de niños lactantes por oligosacáridos de la leche humana en un modelo animal humanizado

AGL2014-52996-C2-1-R

Síntesis de oligosacáridos de la leche humana por medio de glicosidasas de lactobacilos y ensayo de su potencial bioactivo

AGL2010-18696

Exploitation of fucosidase enzymes from Lactobacillus casei directed to hydrolysis and synthesis of fucosyl-oligosaccharides for functional food applications

AGL2007-63060

Bioactive oligosaccharides production by metabolically engineered lactic acid bacteria

AGL2004-03886

Re-routing of the carbon flux in Lactobacillus casei towards D-sorbitol production for functional food applications

Publications

Moya-Gonzálvez E.M., Zeuner Z., Thorhallsson A.Th., Holck J., Palomino-Schätzlein M., Rodríguez-Díaz J., Meyer A.S. and Yebra MJ. 2024. Synthesis of fucosyllactose using α-L-fucosidases GH29 from infant gut microbial metagenome. Applied Microbiology and Biotechnology 108:338.

Muñoz-Provencio D. and Yebra M.J. 2023. Gut microbial sialidases and their role in the metabolism of human milk sialylated glycans. International Journal of Molecualr Sciences. 24, 9994. https://doi.org/10.3390/ijms24129994

Moya-Gonzálvez EM, Peña-Gil N, Rubio-Del-Campo A, Coll-Marqués JM, Gozalbo-Rovira R, Monedero V, Rodríguez-Díaz J, Yebra MJ. 2022. Infant gut microbial metagenome mining of α-L-fucosidases with activity on fucosylated human milk oligosaccharides and glycoconjugates. Microbiol Spectr. Vol. 10, No. 4, e0177522. doi: 10.1128/spectrum.01775-22.

Moya-Gonzálvez EM, Rubio-del-Campo A, Rodríguez-Díaz J. and Yebra MJ. 2021. Infant-gut associated Bifidobacterium dentium strains utilize the galactose moiety and release lacto-N-triose from the human milk oligosaccharides lacto-N-tetraose and lacto-N-neotetraose. Scientific Reports. https://doi.org/10.1038/s41598-021-02741-x. 11:23328.

Rubio-del-Campo A, Gozalbo-Rovira R, Moya-Gonzálvez EM, Alberola J., Rodríguez-Díaz J. and Yebra MJ. 2021. Infant gut microbiota modulation by human milk disaccharides in humanized microbiome mice. Gut Microbes; VOL 13, NO. 1, 1-20 https://doi.org/10.1080/19490976.2021.1914377.

Becerra J.E., Rodríguez-Díaz J., Gozalbo-Rovira R., Palomino-Schätzlein M., Zúñiga M., Monedero V. and Yebra, M.J. 2020. Unique microbial catabolic pathway for the human-core N-glycan constituent fucosyl-alpha-1,6-N-acetylglucosamine-asparagine. mBio 11: e02804-19. https://doi.org/10.1128/mBio.02804-19
Bidart N.G., Rodríguez-Díaz J., Pérez-Martínez G. and Yebra, M.J. 2018. The lactose operon from Lactobacillus casei is involved in the transport and metabolism of the human milk oligosaccharide core-2 N-acetyllactosamine. Scientific Reports 8:7152
Bidart N.G., Rodríguez-Díaz J., Palomino-Schätzlein M., Monedero V. and Yebra, M.J. 2017. Human milk and mucosal lacto- and galacto-N-biose synthesis by transgalactosylation and their prebiotic potential in Lactobacillus species. Appl Microbiol Biotechnol 101:205-215.
Bidart N.G., Rodríguez-Díaz J. and Yebra, M.J. 2016. The extracellular wall-bound beta-N-acetylglucosaminidase from Lactobacillus casei is involved in the metabolism of the human milk oligosaccharide lacto-N-triose. Appl Environ Microbiol 82:570-577
Becerra J.E., Coll-Marqués J.M., Rodríguez-Díaz J., Monedero V. and Yebra, M.J. 2015. Preparative scale purification of fucosyl-N-acetylglucosamine disaccharides and their evaluation as potential prebiotics and anti-adhesins. Appl Microbiol Biotechnol 99:7165-7176

Patents

Request number:
P201431600
Title:
Beta-D-transgalactosidasa de Lactobacillus casei
Date of the request:
Friday, 31 October, 2014
Request number:
N201030438
Title:
Truncated phytases from Bifidobacterium and their uses
Date of the request:
Wednesday, 24 March, 2010

News

Date:

Tuesday, 12 January, 2016